This is because your body breaks them down differently. For example, acetaminophen is broken down and removed by the liver. Acetaminophen has a warning about liver damage it can cause that can be fatal cause death.
Liver damage can happen if you take too much in a hour period. For more information, read about the dangers of acetaminophen overdose. Ibuprofen, on the other hand, is removed from your body by your kidneys. Taking it for a long time can cause kidney damage and stomach bleeding. Using high doses of ibuprofen for longer than recommended can increase your risk of:. Acetaminophen and ibuprofen can cause dangerous interactions when you take them with certain medications.
To reduce your risk, make sure you tell your doctor about all drugs, supplements, and herbs you take. Taking either acetaminophen or ibuprofen may cause problems if you have certain health issues. Talk to your doctor before using acetaminophen or ibuprofen if you have:. Acetaminophen and ibuprofen both treat pain, but they work slightly differently in your body. Each drug can pose different safety issues, especially if you have existing health conditions.
How different can they be? People tend to use it to relieve pain or the symptoms of a mild cold. Like any other drug, ibuprofen can have side effects. One of them is liver damage , though this is rare. As a result, medication can have unintended effects on the liver. To determine the true capacity of ibuprofen to cause liver problems, the researchers regularly administered moderate amounts of ibuprofen to mice for 1 week.
The drug dosage was the equivalent of an adult human taking around milligrams of ibuprofen per day. At the end of the week, the investigators used advanced mass spectrometry — a set of techniques that allow scientists to establish the ratio and type of chemicals present in a laboratory sample at any given time.
Aldrin Gomes. The changes were different, depending on the sex of the mice. In the long term, it is important for the scientific community to start addressing differences between males and females with respect to drug metabolism and effects, he said. Ibuprofen is a widely used and important drug, but is known to have effects on the heart. New research from UC Davis shows that ibuprofen has multiple, unexpected effects on liver metabolism in mice that differ between males and females.
Getty Images. The only treatment for chronic liver failure is to replace your liver with a healthy one from a donor liver transplant. Because it's not possible to know how you'll react to a particular medication, toxic hepatitis can't always be prevented.
But you may reduce your risk of liver problems if you:. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version. Overview The liver Open pop-up dialog box Close. The liver The liver is your largest internal organ. Email address.
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Request an Appointment at Mayo Clinic. Normal liver vs. Share on: Facebook Twitter. Show references Andrade RJ, et al. Journal of Hepatology.
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